Cialis (Tadalafil)

Cialis (medical name Tadalafil) is a good medicine to cure the dysfunction of erection. This medicine has the same effect as Viagra: it restrains PDEase. So to say, it stops those disabilities that are responsible for protein to operate and to be able to do something when someone is doing everything to have an erection. It differs from Viagra by one advantage; you can take this pill not right before sex, but even 24 hours more before coitus. There are some men that take 20 mg of Cialis and can be productive 36 hours after. This long period of time helps to relax and to remove dull thoughts about planning relationships with a partner.

There were made some tests with Cialis and the results showed that those men who had erectile dysfunction made great results in sex after 24 and 36 hours since they have taken a pill. They say that this medicine is like placebo. Also after some clinical studies there were not any incidents with heart attacks detected, because it includes cardiovascular preventive data. All trials showed that the application of Cialis declare the strict and very essential improvement. It shows that the effect does not fade away if person uses it for a long time if you compare it to an ordinary placebo.

Drug and Food Administration of United States had approved tadalafil when they began to sell it in the end of 2003. It is on the third place as a drug against impotence. The other two places were taken by Viagra (sildenafil which is on the first place) and Levitra (vardenafil) on the second place. Comparing to other pills, people call this drug "a week end pill" thanks to its long effect (it acts more than 36 hours).

Everybody should understand that this pill will not increase your sexual desire. If you have an erectile dysfunction, tadalafil will not help you to treat it. Cialis will not protect you from pregnancy or from spreading any diseases that can be transmitted during sexual contact. For example, HIV.


Uses


A summary on Cialis uses


Erectile dysfunction treatment
Erectile dysfunction treatment
 
At the beginning Tadalafil (Cialis) was approved as a drug to be sold by prescription to people that has impotence. Some time had passed and it was discovered that this medicine could cure bladder that was caused by prostate enlarging.

Tadalafil for ED


ED stands for erectile dysfunction sometimes they name it impotence. This disease happens to those that can not reach erection, those people who are not always able to do that and those that have short erections. Impotence is actually a usual inability to keep your penis in erection. This erection should be firm enough to have sex. Once a person gets a prescription to Cialis, he can use it any time. It is important to take it one hour before sex. It can also be taken during the day for an unexpected sex.

How Cialis cures BPH


Benign prostatic hypertrophy
Benign prostatic hypertrophy
 
Men of older age happen to have this disease very often. BPH or benign prostatic hypertrophy is also named popularly as enlarged prostate. This organ is situated under urinary bladder and is one of the organs that are responsible for reproductive system of men. A canal by means of which the urine is taken out of your body is running by way of prostate. So it is very important.

It starts growing in the beginning of adolescence and grows up to the adulthood. And only in the age of 50 or 60 they begin to feel that it is a problem. Once the prostate gland grows big, it starts to push the urethra, which arouses problems with passage of urine. The following are the symptoms that say you have BPH:
  • Very frequent emiction
  • Ache when starting to pass the urine
  • Hard to empty the urinary bladder
  • A need to wake up often to pee
  • Pain during urination
  • An unsteady stream during emiction
  • Spilling after emiction

BPH can be treated only by taking drugs and by surgery. If the symptoms don't bother you, you should just wait. Cialis just cures the symptoms of BPH; it can not do anything to decrease the prostate, unlike the other drugs. But still Cialis is the best medicine to cure your diseases if you happen to have ED and BPH at the same time.


Dosage

Cialis dosages
Cialis dosages
 
If the doctor diagnosed a person and told that he has impotence. He prescribes the right medication and an appropriate dosage for him. The proportions to take the medicine depend on different issues. First of all, it depends on the person's sexual activity, the condition of your health, the drugs you are taking and the stage of the person's impotence.

Cialis dosage has two types. A first one, you can take, when you need it, called standard. Another one is for a long lasting treatment of erectile dysfunction and can be taken each day to be ready at any time. For more information and advises you can contact our team of professionals if you have troubles to define what type you need.

What is a lasting duration and the difference between doses?



10mg and 20 mg of Cialis
People that are in a good health and their condition will stand the effect of Cialis. Those that are not using any other drugs that could harm their health after taking Cialis are prescribed the dosage from 10 mg to 20 mg. This dosage stays in your organism for more than 36 hours after you have taken the pill. That is why this kind of erectile dysfunction treatment is named the week end pill.

This amount of dose is forbidden to take several times every 24 hours. If in your opinion your body will stand to take the pill two times a week, than you should take the daily course. This amount of doses is considered as a need for a person that expects sex and wants to be in a good form.

A small dose of 10mg could be recommended to people that have little Tadalafil precautions considering their condition. This could be when you are afraid of your organism's reaction on ED drugs and you are using some other medicine. And also it is a dosage for those that just want to monitor their condition. Usually a doctor prescribes the first dose of 20mg. Later it could be less, depending on the reaction of your body.

2.5 mg and 5 mg of Cialis Daily
It is a very low dose of a medicine and can be taken each day. In the drug stores they have a much smaller dose that is called Cialis Once Daily and they sell it by prescription. For those that have sex couple of times a week and those that have problem of erectile dysfunction for a long time should take this daily option. It will better for them because the medicine stays in their organism and the joy of unplanned sex will not be a problem.

It doesn't mean that this small dose will not bring you side effects and you can take any other medicine with this drug. It will still remain in your body around-the-clock. So you might have side effects for quite a long time if you are using some drugs that are sensible to Cialis side effects or that can interfere with it. We advise you to talk to your doctor about side effects and try to find some solution before you use other drugs.


Warnings and Precautions

Cialis warnings
Cialis warnings
You should understand that such drugs like Tadalafil are sold only by prescription because they may be dangerous to the patients that have some health problems or if they mix them with other drugs. You should read and think about all the precaution of this medicine very carefully and attentively because if you take them indifferently, it may bring a lot of harm to your health.

Those people that have health problems and take medication each day but their condition is not too bad to forbid them taking this Erectile Dysfunction medicine are in the group of those who cause danger to their health. Still if they want to take this impotence medication they need to know what kind of risks they have when using it. Of course the doctor should know about side effects and give advises on dosage.

There is another group of people that are forbidden to take this medication or any other drug that has PDE-5 inhibitors. It is caused by an old age and a critical health condition, or another medicine that they are taking. They can cause a huge injury to their health and especially to their penis, if they will not take seriously all the warnings.

Cialis forbidden
Cialis forbidden
 

This drug can be used with care if:


  • You had problems with the function of your liver and kidney
  • You have a sickness that includes cardiovascular system.
  • You have sickle cell disease
  • You have a high blood pressure and take medicine to cure it
  • You have an original form of your penis.

It is forbidden to take this medicine if:


  • You are not a man
  • Your age is under 18
  • Your health is in a non-sex condition
  • You have an angina that is uncontrolled
  • Recently you had a stroke or a heart attack
  • You have abnormally low blood pressure
  • You are using different nitrates
  • You have an allergy to components of the medicine
  • You have a kidney failure

These warnings were made by Cialis to prevent you. Decide which group is yours and consult your doctor before you use it. You need to say the truth to your doctor and be honest during your meeting. Any lie will harm your health and bring danger to your penis. Usually doctors give a small dose to their patients. Sometimes they consult you into taking some other medication that will be safer to your condition.

How Cialis works with other drugs


During meeting with your doctor you need to say him everything about your condition and about medicine that you are taking, it doesn't matter if it is herbal or you buy it by prescription or without it. Medical consultant needs to have all your health information in order to give you a good diagnosis and prescribe you a safe and efficient cure.

Some drugs do not comply with the ingredients that Cialis has. It may cause risks and danger to your health when you take this medicine with Cialis. There are some drugs that neutralize the results of ED treatment and you will think that Cialis doesn't help you. You should understand that combinations with tadalafil could produce lethal end. So, it is necessary to make sure that Cialis is the only one medicine that can cure your erectile dysfunction.

Avoid taking Cialis if:


  • You also take nitrates - It will bring you giddiness, weakness and a possible heart failure. Try to avoid such nitrates like glycetol trinitrate, amyle nitrate, and nicorandil. The second nitrate stands for poppers. It is a commercial drug that is widely spread. It can be very dangerous to use this drug together with Cialis.
  • You have an augmented blood pressure - Medications that you use to stabilize it will extremely decrease your blood pressure with Cialis.
  • You use alpha-adrenoceptors blockers - Consult your doctor to decrease the dosage so you can use these two medications together.
  • At this time you are using another ED medicine - It will not help you if you use two ED medications. That can even be worse.


Side Effects

Cialis side effects
Cialis side effects
 
This erectile dysfunction drug can be sold only by prescription from a doctor. Of course there can be some side effects for those who are taking this medicine as it happens to almost all the drugs by prescription. It is not obligatory that this drug will give some side effects to every person that has it. All the people have different reaction to any medication. Sometimes it happens that one man experiences side effects and another one doesn't have them.

Scientists had made lots of researches and trials to study Cialis side effects. The surveys and clinical trials had been made with about 15,000 of men. Eight million men all over the world had been tested and the results showed that they are really satisfied with the product. Considering all this we can say that some of side effects are very frequent and some of them are rare.

Frequent side effects


Frequent side effects
Frequent side effects
 
These effects are quite simple and can arise for just a short time when people are using this drug. First of all you should go to a doctor if you see that you are having some side effects by having physical discomfort after taking Cialis. Some essential ingredients could stay in your body for a long time. Their active life can make you feel uncomfortable since you use this medicine for a long time. If it happens, you should go to your doctor and talk to him concerning taking the other dosage.

These are usual side effects:
  • Regular headache
  • Difficulty in digesting food
  • Pain in the back
  • Pain in muscles
  • Regular blush
  • Regular stuffy nose

Rare side effects


You are not in danger and don't worry if you have any of the following side effects after taking tadalafil. People just experience these side effects more rare than the others. That is why we placed them to the rare ones. You need to chat with your medical instructor if you happen to have these side effects and they bother you.

These are following rare side effects:
  • Lack of water in your mouth
  • Feeling regularly tired
  • Ache in muscles and chest
  • Frequent heartbeat
  • Heart rate growth
  • Feeling of revulsion
  • Skin eruption

Uncommon side effects


These side effects could occur infrequently. If you once experienced any of the following, you should go to the hospital straightaway. Be sure that you are not using this erectile dysfunction medicine with any other drugs that can cause such strong side effects. Sometimes it happens that a person is allergic to some component that consists in this medicine or your organism reacts to the medical condition that is unknown to it.

The following are uncommon side effects:
  • Apoplexy or heart attack
  • Your blood pressure suddenly decreases or increases
  • Noise bleeds and you feel weak
  • Prolonged painful erection of penis



Mechanism of action

The erection takes place when nitric oxide releases to the physiological process of erection involves the release of nitric oxide (NO) to the cavernous body of intromittent organ. NO increases the amount of cGMP when it binds with receptors of ferments of enzyme guanylate cyclase. The erection takes place when the flow of blood increases thanks to the cGMP that helps to relax the blood vessels muscular walls.

Cialis formula
Cialis formula
 
Cialis is a strong and precious PDE5 inhibitor. Walls of lungs and ponile arteries contain enzyme which helps cGMP to degrade in the cavernous body. Cialis chemical structure resembles to the structure of cGMP in a certain way, and can compete with it by how it binds with PDE5. It increases the amount of cGMP and makes erections much better. Sexual stimuli activates cGMP/nitric oxide, cialis can not generate erection if there will not be any of these stimulants. The same operation schemes have Levitra (vardenafil) and Viagra (sildenafil).

Cialis effects greatly on cGMP that is why there has been made a lot of studies concerning its probable cure of pulmonary arterial hypertension. When people use cialis, the resistance and pressure reduces in pulmonary arteries, arteries in longs open, right chamber of heart works less hard.


History

Viagra was approved as a prescription medicine by FDA on March, 27th in 1998. For five years, Pfizer Inc. was the only one company that could sell medicine for stimulating erection that had citrate of sildenafil. From the time they were introduced and during the next five years they had disposed to purchasers over $1 billion of this medicine. On 19th of August in 2003 when FDA approved Levitra and a few months later when Cialis has also been approved, the situation totally changed.

Cialis history
Cialis history
 
A medicine Cialis for erectile dysfunction prescription was developed under interesting circumstances. In 1993 a pharmaceutical company Icos began to make studies concerning IC351 which is an enzyme inhibitor of PDE5. This process happens when the drug tries to overcome impotence. One year later, people from Pfizer who made clinical researches in cardiology discovered that sildenafil citrate causes erection when they observed patient's heart.

It is interesting to know that when all the tests with IC351 were conducted, the only test for erectile dysfunction has not been made. No one knew that this chemical compound has the same characteristics as sildenafil citrate. A drug company Pfizer discovers an implicit impotence medicine a year after that.

Icos, a company that was founded in Washington, began to make their researches in 1990 and four years later they obtained their first patent for IC351. But unfortunately it was too late, since the appropriate drug was found by Pfizer. In 1995 they started the first Phase of clinical studies. Couple of years later they began a second phase of trials. This was the longest phase of two years. During this period they decided to make studies with patients that had impotence until they reached the last third phase.

Together with another company Eli Lilly and Co, in 1998, Icos decided to crash the impotence drug market. In the year 2000, a new application of drug IC351 has been registered by FDA with a company that had a new name Cialis drugs.

The third phase of trials had begun in May 2002 when Lilly Icos had claimed to American Urological Association about their testing Cialis. It was exposed that this drug stays in body and continues working for more than 36 hours. This information was revealed in Orlando, Florida on an American Urological Association annual meeting.

They also ratified this medicine in Europe 6 months later. On the 21st of November in 2003, it was finally approved by FDA.


Generic Cialis


Is there a non-licensed version?


Generic Tadalafil
Generic Tadalafil
 
Cialis also known as tadalafil is a medicine that sold by prescription and was approved to cure ED (erectile dysfunction). Also it has a license to treat symptoms of enlarged prostate. Eli Lilly has a patent to manufacture this medication and it is forbidden to manufacture generic Cialis by any other company. Still you may find a list of companies that sell it, if you type "Generic Cialis" in the Internet searching site. We can not guarantee safety and effectiveness of these fake medicines. We do not recommend you to buy generic Cialis, only if you will find an officially approved version.

When will I find unpatented version?


Eli Lilly has a patent to produce Cialis until 2016. From that year you can find a generic version of Cialis. Still this period can be prolonged under some circumstances. It may occur that someone can find another way of using Cialis or a lawsuit will forbid producing it. When Cialis will loose its patent, the other company will have a full right to produce this medicine.

Is Tadalafil a non-licensed version of Cialis?


No - it is just one of the main ingredients in Cialis. It had never been its non-licensed version. Some people misunderstand tadalafil and generic version of Cialis. Actually, this version differs a lot from the drug's main ingredient. If another manufacturer wants to produce a generic version of the product, the real manufacturer should loose its patent.


Drug interactions

When you use this medicine with some other drugs, it may bring leaps of your blood pressure, and the organism will assimilate the drugs in other way as it was supposed to. The following medicine can possibly interact with Cialis: alpha blockers, ritonavir and alcohol. Your doctor can give you some advices if you ask him about the interactions of Cialis with other medicine.

There is a number of drugs with which Cialis can possibly interact:
  • Alcohol
  • CYP 3A4 inhibitors
    CYP 3A4 inhibitors
     
  • CYP 3A4 inhibitors:
    • Amprenavir (Agenerase)
    • Atazanavir (Reyataz)
    • Clarithromycin (Biaxin)
    • Conivaptan (Vaprisol)
    • Darunavir (Prezista)
    • Delavirdine (Rescriptor)
    • Erythromycin
    • Fosamprenavir (Lexiva)
    • Imatinib (Gleevec)
    • Indinavir (Crixivan)
    • Isoniazid
    • Itraconazole (Sporanox)
    • Ketoconazole (Nizoral)
    • Lopinavir and ritonavir (Kaletra)
    • Miconazole
    • Nefazodone (Serzone)
    • Nelfinavir (Viracept)
    • Nicardipine (Cardene)
    • Posaconazole (Noxafil)
    • Quinidine
    • Ritonavir (Norvir)
    • Saquinavir (Fortovase, Invirase)
    • Telithromycin (Ketek)
    • Voriconazole (VFEND)
  • Alpha blockers
    Alpha blockers
     
  • Alpha blockers for benign prostatic hyperplasia (BPH) or high blood pressure (HBP):
    • Alfuzosin (Uroxatral)
    • Doxazosin (Cardura)
    • Phenoxybenzamine (Dibenzyline)
    • Phentolamine (Regitine)
    • Prazosin (Minipress)
    • Silodosin (Rapaflo)
    • Tamsulosin (Flomax)
    • Terazosin (Hytrin)
  • Blood pressure medications
  • Nitrates
    Nitrates
     
  • Nitrates:
    • Isosorbide dinitrate (BiDil, Dilatrate SR, Isochron, Isordil)
    • Isosorbide mononitrate (Imdur, Ismo, Monoket)
    • Nitroglycerin tablets or capsules (Nitrostat, Nitro-Time)
    • Nitroglycerin ointment (Nitro-Bid)
    • Nitroglycerin anal ointment (Rectiv)
    • Nitroglycerin patches (Minitran, Nitro-Dur)
    • Nitroglycerin spray (Nitrolingual, NitroMist)
  • Other phosphodiesterase type 5 inhibitors (PDE5 inhibitors):
    • Avanafil (Stendra)
    • Sildenafil (Viagra, Revatio)
    • Tadalafil (Adcirca, Cialis)
    • Vardenafil (Levitra, Staxyn)
  • Theophylline (Elixophyllin, Theochron, TheoCap, Theo-24, Uniphyl)


Alpha blockers
When you combine Cialis with this type of medicine you can decrease the pressure in your blood. (there were situations when such blood pressure was very dangerous). Still you need to ask your doctor when you begin taking these two medicines at one time.

Alcohol
You will have an accelerated rate of the heart, sometimes headaches, giddiness, decreased pressure of blood if you take this drug with a lot of alcohol.

Various medications for blood pressure
Your blood pressure will be too decreased if you begin to use this drug with the medicine for high blood pressure. Ask your doctor if you can take these two medicines together.

Inhibitors of CYP 3A4
CYP 3 A4 enzymes that are situated in liver, could be metabolized by Cialis. There are other drugs (they call them inhibitors of CYP 3A4) that can slow down the action of enzymes. This process raises the amount of Cialis in your blood and may bring dangerous side effects. So, prior to taking this medication, you should consult with your doctor.

Nitrates
When taking Cialis, it is forbidden to take nitrates. Don't think, that if you take nitrates seldom, it will not harm you. In any case when a person takes Cialis he can not tell for sure, when it will be necessary for him to use nitrates.

Other PDE5 inhibitors
This medication belongs to PDE5 inhibitors. You can not take it with other drugs even if the do not help to cure ED.

Theophylline
Your heart rate will be increased if you use this medicine and theophylline. Ask your doctor to do some adjustments on dosage for these two medicines.

Conclusion


We admit that may be not all the interactions of Cialis with other drugs were described in the foregoing text. In any case, you need to talk t your doctor about the possible drug interactions with Cialis that you may experience.

General keywords

User discussion about Cialis

Damion
25 August 2012
I had problems with having long lasting and hard erections. My first experience with Cialis was last month and it was a pill of 10mg. I really like the medicine and I don't have any side effects. The medicine lasts for more than 24 hours and it is easy to take it.
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Garrett
06 September 2012
The medicine is awesome! I recommend taking a 20mg pill instead of 10mg. You can be sure that the erection will take place when you take a 20mg pill.
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Devin
15 October 2012
During the last year I have been taking a 20mg pill of this medicine. I realized that the effect is better when you take the pill with food that has a lot of fat. The action goes during three days and there is no inconvenience to finish the sexual intercourse. I didn’t have any side effects, except a slight headache one time after first day of treatment.
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Marquis
15 November 2012
I tried this medicine two times and both of them were great! I had doses of 10mg. The effect was during 48 hours and I didn’t see any side effects.
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Doug
18 March 2016
Has anybody noticed their erection dosen't feel natural? Mine feels hard and numb.
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