Aleve (Naproxen)

Aleve (Naproxen) belongs to the type of nonsteroidal inflammatory drugs (NSAIDs). This medicine helps to reduce hormones that make pain and inflammation in your body.

Inflammation and pain that were caused by such diseases, like tendinitis, menstrual cramps, bursitis, arthritis, gout or ankylosing spondylitis are often treated by Aleve.

It also can be applied in other conditions that are not pointed in our medication guide.

Aleve (naproxen) is a medicine that can give a huge risk of strong heart problems sometimes with fatal end. It may also cause problems with blood vessels, such as stroke or a heart attack. If you are using Aleve for quite a long time or you have problems with your heart at this stage already, this risk may be more increased. If a person had just or is going to have a bypass surgery on his heart, he is forbidden to take Aleve.

Aleve may be the reason of serious stomach bleeding or ulcers which can have a fatal outcome. It may also bring difficulties to old people. These difficulties can appear without any warnings.





Uses

Pain
Pain
 
The medicine makes pain and ache go away temporarily. When you caught cold, it may cure such symptoms as pain in the back, arthritis, teeth pain, ache in muscles and pain during periods. Sometimes people use it to reduce the body temperature. Your doctor can advise you for what else you may use it.

Aleve belongs to NSAID. It is not determined how this medicine works. There are estimations that it blocks something in your body to reduce inflammation. Drugs of this type are used to treat inflammation and pain symptoms. But unfortunately it can not cure the sickness that was a reason of these symptoms.

Aleve is forbidden for those who have:


Aleve review
  • Pregnancy in the past three months you are allergic to any ingredient in Aleve;
  • A strong allergic reaction, like giddiness, urticaria, neoplasm in their nose, strong eruption and troubles when they breath;
  • An allergic reaction to NSAID like celecoxib, asperin or celecoxib;
  • Allergy to Aleve components you have;
  • Or had a disease that needed a surgery on heart;
  • A disease that needs to use drugs that have naproxen;

If any of these conditions apply to you, consultation with a doctor is strictly needed.


Dosage

Aleve dosage
Aleve dosage
Most often produce Aleve in tablets doses of 220 mg, 250 mg 500 mg and 550 mg. The dose of Aleve is needed to slow down the incident of inflammation which became the result of diseases like arthritis. Aleve dosage is conveniently classified for two categories: for adults and for children. In the same way, each class is divided into maximum and minimum. Maximum dose will help both the patient and the doctor to define how much of the medicine one should take considering strong side effects.

Dosage for children


Aleve can be prescribed to certain kids to treat inflammation. This medicine can be given to children at an early age. Still you should remember about several cautions. You need to be definite to give this medicine to your child and make him go through a serious check-up by a good doctor. Only in this case, if everything went well and your doctor agreed, you can give the medication to your child. We give you the dosage of Aleve for children. The maximum is 5.0 mg/kg. 21.0 mg/kg is for those kids who are younger than 2 years. This dose had not yet been established as valid. So, you can abstain from giving this medicine to a kid who is below the age of two. These were given to protect from future risks and avoid difficulties.

Dosage for grown-ups


Comparing to little children, people of older age can agree on using a higher dose of Aleve. It explains why we put below a higher dosage. The naproxen sodium needs to work inside your body that is why you need to take more of Aleve. It helps to decrease the amount of inflammation in the parts of your body. The following is the dosage for older age. Maximum dosage of Aleve for Adults is 1650 mg. 275 mg is the Minimum Dosage of Aleve. The maximum Aleve dose is needed to be taken during 24 hours. Be careful with overdosing, it may be harmful to your health. Everything will be fine if you will take the maximum dosage.


Warnings and Precautions

It is simply possible to use Aleve with other drugs especially that can cure pain, inhibitors of ACE, lithium, some medications for diabetics, beta blockers, antibiotics and diuretics. Consultation with a doctor will secure the accuracy and safety of treatment.

People who are allergic to NSAIDs or have asthma should not take Naproxen. Also it is forbidden for those who have problems with cardio system, who had gastrointestinal bleeding, people with nephritic problems and pregnant women. For any information you still need to consult with your doctor.


Side Effects

Blurred vision
Blurred vision
 
You should immediately contact a doctor if you experienced any of these factors: swelling of your lips, throat, tongue or face; if it is difficult to breath. If you are having any of the following side effects that are serious, you should immediately cease using Aleve and go to a doctor:
  • If the excretions are bloody, dark or tarry;
  • Pain in chest, sight problems, balance problems, short breath, weakness, indefinite conversation;
  • Chills, pain in the head, crimson skin spots, convulsions, stiffness in neck, high temperature, being sensitive to light;
  • Pain in throat, skin peels, fever, rash of red skin, blisters and headache;
  • Low or absence of urination;
  • Pain in stomach, appetite absence, light brown excretions, vomiting, dark urine, yellow eyes and skin, low temperature;
  • Numbness, tingling in ears, pain, weak muscles;
  • Fast gain of weight or body swelling;
  • Coughing of blood or vomiting with brown substance;

Side effects that are not very serious can be:

  • Smokey vision;
  • Rash and itching of skin;
  • Stomach pain, tingling in ears, diarrhea, headache ;
  • Gas, bad vision;
  • Blurred vision;

These side effects are not all the conditions that could occur to the person that is using Aleve. More information about side effects can give your doctor.


Mechanism of action

The usual mechanism of action of NSAID and naproxen is connected with blocking the activity of cyclooxygenase. Mammals' studies have depicted two most unique cyclooxygenases. This essential component makes the synthesis of prostaglandins, which is needed to make stomach and kidneys work better. Prostaglandin that takes part in inflammation is generated by inducible cyclooxygenase. Toxicity of stomach and kidney is thought to be caused by inhibition of COX-1. At the same time, inhibition of COX-2 helps to prevent inflammation.


History

Syntex Corp. had developed naproxen and in 1976 began to sells it with a name Naprosyn.


Aleve ad
Patents do not protect the copies of this drug and their generics any more. Usually, you can find them not so expansive comparing to the proprietary. Considering the statistics of a drug information service that is located in New Jersey, the total of sales in both branded and generic versions, was 218 million dollars last year.

As naproxen, Ivax is a medicine that people usually use to cure acute gout, juvenile arthritis, rheumatoid arthritis tendinitis and bursitis, osteoarthritis and some other diseases. American Food and Drug Administration had approved only one brief application of a new drug for Zenith and for Ivax, last year. This year Ivax is going to get some new approvals from about forty requests that are still in the agency.

Company's representative Joe Jones, says that they expect to sell medicine in tablets in about four weeks. Joe Jones can not say what will be the revenue from the naproxen selling in 1995. Ivax had given to its company an income of one billion dollars for the last year.


Overdose

If it occurred to you that you've overdosed the use of Aleve, immediately contact a doctor. The symptoms that should scare you are: pain in stomach, dormancy, coughing with blood, coma, vomiting, dizziness, shallow breathes, dark stool or fainting.


Storage

The temperature in the room where Aleve is stored should be between 20 and 25 degrees C, or 68 and 77 degrees F. An impossible for Aleve temperature in the room is 40 C or more than 104F. Try to keep it away from light, moisture and heat. Don't keep Aleve in bathroom. Avoid placing Aleve near pets and children.


Drug Interactions

In the chapter below, we retell what dangerous interactions may happen to you if you combine naproxen with one of the foregoing matters.
  • ACE (Angiotensin-converting enzyme) inhibitors:
    • Benazepril-hydrochlorothiazide (Lotensin HCT), benazepril (Lotensin), or benazepril-amlodipine (Lotrel)
    • Captopril-hydrochlorothiazide (Capozide) or Captopril (Capoten)
    • Enalapril-hydrochlorothiazide (Vaseretic), enalapril (Vasotec), or enalapril-felodipine (Lexxel)
    • Fosinopril-hydrochlorothiazide (Monopril-HCT) or fosinopril (Monopril)
    • Lisinopril-hydrochlorothiazide (Prinzide, Zestoretic) or lisinopril (Prinivil, Zestril)
    • Quinapril-hydrochlorothiazide (Accuretic, Quinaretic) or quinapril (Accupril)
    • Ramipril (Altace)
  • Angiotensin II receptor blockers (ARBs):
    • Azilsartan/chlorthalidone (Edarbyclor), azilsartan (Edarbi)
    • Candesartan-hydrochlorothiazide (Atacand HCT), candesartan (Atacand)
    • Eposartan-hydrochlorothiazide (Teveten HCT), eposartan (Teveten)
    • Irbesartan-hydrochlorothiazide (Avalide), irbesartan (Avapro)
    • Losartan-hydrochlorothiazide (Hyzaar), losartan (Cozaar)
    • Olmesartan-hydrochlorothiazide (Benicar HCT), olmesartan (Benicar), or amlodipine and olmesartan (AZOR)
    • Telmisartan-hydrochlorothiazide (Micardis HCT), telmisartan (Micardis)
    • Valsartan-hydrochlorothiazide (Diovan HCT), valsartan (Diovan)
  • Aleve vs beta blockers
    Aleve vs beta blockers
     
  • Beta blockers:
    • Acebutolol (Sectral)
    • Atenolol (Tenormin)
    • Betaxolol (Kerlone)
    • Bisoprolol (Zebeta)
    • Carvedilol (Coreg, Coreg CR)
    • Esmolol (Brevibloc)
    • Labetalol (Trandate)
    • Metoprolol (Lopressor, Toprol-XL)
    • Nadolol (Corgard)
    • Nebivolol (Bystolic)
    • Penbutolol (Levatol)
    • Propranolol (Inderal, Inderal LA, InnoPran XL)
    • Sotalol (Betapace)
    • Timolol
  • Bile acid sequestrant cholesterol medications: Cholestyramine (Prevalite, Questran, Questran Light), Colesevelam (WelChol), Colestipol (Colestid)
  • Corticosteroids: Betamethasone (Celestone), Cortisone, Dexamethasone (Decadron), Fludrocortisone (Florinef), Hydrocortisone (Cortef), Methylprednisolone (Depo-Medrol, Medrol), Prednisolone (Ovapred, Pediapred), Prednisone, Triamcinolone (Kenalog, Aristospan)
  • Cyclosporine (Gengraf, Neoral, Sandimmune)
  • Digoxin (Digitek, Lanoxin)
  • Aleve vs diuretics
    Aleve vs diuretics
     
  • Diuretics:
    • Amiloride-HCTZ (Moduretic), amiloride (Midamor)
    • Bumetanide (Bumex)
    • Chlorothiazide (Diuril)
    • Chlorthalidone (Thalitone)
    • Ethacrynic acid (Edecrin)
    • Furosemide (Lasix)
    • Hydrochlorothiazide (Esidrix, HydroDIURIL, Oretic, Microzide)
    • Metolazone (Zaroxolyn)
    • Spironolactone-HCTZ (Aldactazide), spironolactone (Aldactone)
    • Torsemide (Demadex)
    • Triamterene/HCTZ (Dyazide, Maxzide), triamterene (Dyrenium)
  • Lithium (Eskalith, Lithobid)
  • Drugs that "thin" the blood or otherwise increase bleeding risk (such as antiplatelet and anticoagulant drugs):
    • Antithrombin (ATryn, Thrombate III)
    • Argatroban
    • Aspirin (Bayer and others)
    • Bivalirudin (Angiomax)
    • Cilostazol (Pletal)
    • Clopidogrel (Plavix)
    • Dabigatran (Pradaxa)
    • Dipyridamole (Persantine)
    • Drotrecogin alfa (Xigris)
    • Eptifibatide (Integrilin)
    • Fondaparinux (Arixtra)
    • Heparin or heparin-like products, including dalteparin (Fragmin), enoxaparin (Lovenox), or tinzaparin (Innohep)
    • Lepirudin (Refludan)
    • Other nonsteroidal anti-inflammatory drugs (NSAIDs): Celecoxib (Celebrex), Diclofenac (Cambia, Solaraze Gel, Zipsor, Cataflam, Flector, Voltaren, Voltaren Gel, Voltaren-XR, Voltaren Ophthalmic), Etodolac (Lodine, Lodine XL), Ibuprofen (Motrin, Advil, Nuprin), Ketorolac (Toradol), Indomethacin (Indocin, Indocin SR), Ketoprofen (Orudis, Actron, Oruvail), Meloxicam (Mobic), Nabumetone (Relafen), Oxaprozin (Daypro), Piroxicam (Feldene)
    • Prasugrel (Effient)
    • Thrombolytics: Alteplase (Activase), Reteplase (Retavase), Streptokinase (Streptase), Tenecteplase (TNKase)
    • Ticlopidine (Ticlid)
    • Tirofiban (Aggrastat)
    • Warfarin (Coumadin, Jantoven)
  • Methotrexate (Rheumatrex, Trexall)
  • Probenecid (Benemid, Probalan)
  • SSRI or SNRI medications: Citalopram (Celexa), Desvenlafaxine (Pristiq), Duloxetine (Cymbalta), Escitalopram (Lexapro), Fluvoxamine (Luvox, Luvox CR), Fluoxetine (Prozac, Sarafem, Selfemra), Milnacipran (Savella), Sertraline (Zoloft), Paroxetine (Paxil CR, Paxil, Pexeva), Venlafaxine (Effexor XR, Effexor)


ACE Inhibitors
When you mix ACE inhibitors with naproxen you are likely to get problems with kidney. Particularly it is applied to people that already have problems with them. This combination may also prevent the action of ACE inhibitor to reduce blood pressure.

ARBs
When you combine ARB with naproxen, you are likely to have more problems with kidney. Usually it happens to those patients that already have problems with kidneys. It may prevent the action of the medicine that reduces pressure of the blood.

Beta Blockers
Combining naproxen with a beta blocker may interfere with the beta blocker's ability to lower blood pressure. You need to talk to your doctor prior to using both of these drugs.

Bile Acid Sequestrants
Naproxen can be bound to bile acid sequestrants in your digestive tube and can postpone the absorption of the medicine into your body. If you don't want to have such interaction you should take one of the medicines some time before you take the other one.

Corticosteroids
When a patient takes naproxen with corticosteroids, he might bleed more often. It is better to ask a doctor to investigate you more often and see what dose of medicine will be appropriate for you.

Cyclosporine
The amount of cyclosporine in your blood could be increased if you take it with naproxen. Therefore cyclosphorine's side effects will be also increased. This unit can also bring more damage to your kidney. You should talk more to your doctor about combining these two medicines.

Digoxin
The use of this medication can raise the amount of digoxin in your organism, and the side effects from taking it will be more dangerous. When a patient is taking digoxin, he should ask the doctor if he can stop or start taking naproxen.

Diuretics
When you take diuretic with naproxen, the problems with your kidney will occur more and it concerns people that have them already. The quality of action of the diuretic will be reduced too.

Lithium
When you take lithium and naproxen at one time, it could rise up the amount of lithium in your organism, in such a way, the kidney will work worse for removing it. The doctor should work to maintain the amount of lithium in your organism and he can make some adjustments concerning dosing of medicine.

"Thinners of blood" and other drugs that are similar to it
When you combine anticoagulants and naproxen together, or antiplatelet medicine, or some other drugs that may provoke bleeding, can bring danger with bleeding, which may also include bleeding inside your body. Never mix these two types of medication until you talk to your doctor and he approves it or maintains your treatment.

Methotrexate
The risk of toxicity of methotrexate may be increased when taking it with naproxen. You should first talk to your doctor and ask for his approval and maintenance before you start combining these two drugs.

Probenecid
When you take both naproxen and probenecid at one time, it can raise the amount of naproxen in your blood. Your doctor may ask you to take a lower dose and be more attentive to you.

SNRIs or SSRIs
When a patient combines serotonin-norepinephrine reuptake inhibitor (SNRI) and selective serotonin reuptake inhibitor, he will get more risk to bleed. It is necessary to talk to your doctor when you are planning to take SNRI or SSRI with naproxen.

Nutritional or/and Herbal Supplements
There are some nutritional and herbal supplements that can react upon the action of naproxen and raise the danger of bleeding. Before you start therapy with naproxen, you should discuss with your doctor if you can take herbal or natural supplements with it.

Conclusion


We assume that we didn't discuss all the interactions of this drug. That is why your pharmacist or your doctor should tell about all the possible interaction with other drugs when you take naproxen and it can be applied to you.

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User discussion about Aleve

Carlos
21 August 2012
I am fond of Aleve, but take my advice: before it's consumption everyone should visit a doctor. Sometimes I have sharp pain in my toes and headaches because of TMJ syndrome. The medicine helped me in both cases. In some cases it can provoke stomach bleeding or even heart attack, so firstly go to doctor!
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Leo
05 September 2012
After tearing my rotator cuff, I started taking aleve for shoulder pain. Took 2-6 per day for three months. Passed out going to the bathroom one night rushed to the hospital. i was losing blood through a hole in my stomach which was caused by the Aleve. Required 5 pints of blood. Avoid Aleve
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Thomas
22 September 2012
I took two Aleve a day to calm my back pain and it helped, but eventually it had bad influence on my stomach. My doctor understood everything, so I've dropped to consume it completely. After a year of invariable nausea and ache, I was forced to quit taking it.
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Kathy
01 November 2012
I was taking Aleve as an anti-inflammatory to help with pain produced by scleroderma and unfortunately I was forced to stop. After 4 days on the drug I suffered profuse bleeding from my large colon, actually went into shock and had to go to ER. Sad because the drug did give me a lot of pain relief.
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Beckett
20 February 2013
It works. When I had felt intensive pain, I took Aleve an hour later. Firstly I took 2 tablets then one every eight hours. I think that I will take it couple days. It helps to get out of gout very fast.
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