Cholesterol: HDL, LDL, VLDL, triglycerides

HDL cholesterol, LDL, VLDL, triglycerides... What is good and bad cholesterol? In this paper we explain the causes and consequences of high cholesterol.

Cholesterol
Cholesterol
 


What is cholesterol?

We hear much talk about good and bad cholesterol, but little is said about its real meaning.

Cholesterol is a fatty substance found in every cell in our body. It is essential for the formation of membranes of our cells, for the synthesis of hormones such as testosterone, estrogen, cortisol and other for the production of bile, for digestion of fat, for formation of myelin (a sheath covering nerve), for metabolism of some vitamins (a, D, E and K), etc..

The cholesterol in our body has two origins:
  • Endogenous - produced by our own body, especially the liver.
  • Exogenous - acquired through food.


Types of cholesterol

Types of cholesterol
Types of cholesterol
 
Since this is a fatty substance, cholesterol does not dissolve in blood, it is equal to the oil droplets in water. Therefore, to travel through the bloodstream and reach the peripheral tissues, cholesterol needs a carrier. This function belongs to lipoproteins that are produced in the liver. The main ones are:
  • VLDL (Very low-density lipoprotein)
  • LDL (Low-density lipoprotein)
  • HDL (High-density lipoprotein)

LDL transports cholesterol and triglycerides from the liver to the tissues. The triglycerides and VLDL carries some cholesterol. HDL is a different carrier, it does the opposite way, takes cholesterol from tissues and returns it to the liver and excretes it in the intestines.

While the LDL and VLDL lead cholesterol to the cells and facilitate the deposition of fat in the vessel, the HDL is on the opposite promotes the removal of excess cholesterol, including arterial plaques. So called good cholesterol is referred to HDL, while VLDL and LDL is known as bad.

The production is regulated by lipoprotein cholesterol levels. Cholesterol derived from saturated fats and trans fats favor the production of LDL, whereas the consumption of unsaturated fats, found in oil, fish, and nuts, for example, promote production of HDL.

Therefore, the doses of lipoprotein carriers LDL, VLDL and HDL have an indirect assessment of the quantity and quality of the cholesterol circulating in our blood.


What is atherosclerosis?

Atherosclerosis
Atherosclerosis
 
High concentrations of VLDL and LDL are associated with the deposition of fat in the blood vessel wall leading to the formation of cholesterol plaques. When our body has more cholesterol than it needs, the molecules of LDL circulating in the blood are looking for some fabric that is in need of cholesterol for its operation. If the cholesterol is not delivered to any tissue, the LDL molecule ends up depositing in blood vessels, accumulating fat in them. This process is called atherosclerosis.

See the illustration on how these fatty plaques take up space and reduce the diameter of the vessel lumen (the channel within a blood vessel or the cavity within a hollow organ). Atherosclerosis also causes direct damage to the wall, reducing the elasticity of the arteries, making it harder.

The fat deposits and vessel wall injury favor the obstruction of blood flow and reduce the supply of oxygen and nutrients to tissues. When the vessels affected by cholesterol plaques are the coronary arteries (heart arteries), the result can be heart attack, when cerebral vessels are affected, the patient may present with an AVC.


Dyslipidemia

The increased level of cholesterol is called dyslipidemia. For a long time doctors evaluated the degree of dyslipidemia with values of total cholesterol, which is nothing more than the sum of the blood levels of HDL + LDL + VLDL. However, as just explained, there is good and bad cholesterol, which makes efficient joint evaluation of them. Currently the total level is less valued than the individual levels of HDL and LDL.

See these examples:
Patient 1 - LDL 150, HDL 20 and VLDL 20 = total cholesterol of 190
Patient 2 - LDL 100, HDL 65 and VLDL 25 = total cholesterol of 190

From what has been explained so far, there is no doubt that the first patient presents a greater risk of atherosclerosis than patient 2, despite having the same total cholesterol level. The above example explains why the total level is not the best parameter for assessing the dyslipidemia.


Values of HDL and LDL cholesterol

Cholesterol tester
Cholesterol tester
As dyslipidemia is a major risk factor for cardiovascular disease, medicine has attempted to establish, through studies, which are the optimal levels of HDL and LDL. Currently the classification of cholesterol is as follows:

Low-density lipoprotein


Less than 100 mg / dL - Optimal
Between 101 and 130 mg / dL - Normal
Between 131 and 160 mg / dL - Normal / High
Between 161 and 190 mg / dL - High
Greater than 190 mg / dL - Very High

High-density lipoprotein


Less than 40 mg / dL - Low (bad)
Between 41 and 60 mg / dL - Normal
Greater than 60 mg / dL - High (best)


What to do when your cholesterol is high?

Unsaturated fats food
Unsaturated fats food
 
A diet rich in unsaturated fats and low in saturated fat is recommended for all people, regardless of the value of their cholesterol. But if you have dyslipidemia, following this diet is even more important.

However, it alone does not always solve the problem of high cholesterol, because the increase in LDL is related to genetic factors and food. 75% of our cholesterol is of endogenous origin (produced by the liver) and only 25% comes from the feed. So if the LDL values are very high, diet alone is not sufficient to normalize the values of the bad cholesterol.

Physical exercise helps raise HDL and lower LDL, and it is another option to control dyslipidemia. However, as in the diet, the reduction is not large. Diet and exercise are sufficient for those patients with LDL to 160 mg / dl. This is the group that can achieve good results without resorting to drugs.

The decision of when to start taking the drugs depends not only on the values of LDL and HDL, but also the presence of other risk factors for cardiovascular disease, including:
The more risk factors you have, the lower your cholesterol should be. Roughly speaking, we can summarize the targets as follows:
  • Patient with only one risk factor - LDL should be less than 160 mg / dL
  • Patients with two or more risk factors - LDL should be less than 130 mg / dL
  • Patients with high cardiovascular risk, especially those, who have had a heart attack or stroke - LDL should be less than 100 mg / dL

More recent studies begin to suggest that an LDL below 80 is ideal for high-risk patients. The very low HDL is also considered a risk factor, not even with very high LDL. You can already start treatment just based on their value.

Is it bad to have too high HDL?


Some people, usually women, have very high HDL, sometimes greater than 100 mg / dL. This does not indicate any disease. In fact, people are lucky because they have low risk of heart disease, especially if your LDL is low.


What are the symptoms of high cholesterol?

High cholesterol does not cause symptoms. Caution: high cholesterol does not cause fatigue, headache, shortness of breath, prostration or any other symptom. Dyslipidemia is a silent disease. The only way to know the level of cholesterol is via the analysis of blood.


Triglycerides

Hypertriglyceridemia, name given because of the increase of triglycerides in blood, is also a risk factor for atherosclerosis, especially if combined with low HDL.

Triglycerides are closely linked to VLDL and their value is typically 5 times greater. For example, an individual with VLDL 30 mg / dl, will have about 150 mg / dL triglycerides.

Normal values of triglycerides are:


Up to 150 mg / dL = normal
Between 150 and 199 mg / dL = borderline
Between 200 and 500 mg / dL = high
Greater than 500 mg / dL = very high

Treatment of lower triglycerides consists of regular aerobic exercise, weight reduction and control of the intake of carbohydrates (pasta, sweets, soft drinks ...) and alcohol.

The diet combined with sports is more successful in lowering triglycerides than on LDL, especially for males. While most patients with high cholesterol end up needing drugs, patients can control their triglycerides without resorting to drugs.

Elevated cholesterol and especially triglycerides, are associated with a higher incidence of fat accumulation in the liver called hepatic steatosis.

Similarly that may be genetic hypercholesterolemia, hypertriglyceridemia, too. There are cases of triglycerides greater than 1000 mg / dL (I've seen up to 4000 mg / dL). In these individuals the blood is so fat that appears to be milky. Unreasonably high triglycerides increase the risk of acute pancreatitis.


Medications used to treat high cholesterol (hyperlipidemia)

All patients with cholesterol and / or high triglycerides should be submitted to the diet, exercising regularly, and if they're overweight, lose weight.

The drugs for lowering LDL and HDL are the statins, inhibitors also named enzyme HMG-CoA reductase (liver enzyme responsible for the production of cholesterol). Statins also act to reduce triglycerides.

Statins
Statins
 
The most frequently prescribed statins are:
  • Simvastatin
  • Atorvastatin
  • Fluvastatin
  • Pravastatin
  • Rosuvastatin
  • Lovastatin

Rosuvastatin and atorvastatin are the strongest and manage cholesterol reductions with lower doses. However, when compared at equivalent doses, there is no difference in the results of all statins. Therefore, the choice should be individual, based on economic conditions and the patient's adaptation to the drug. In the end, all statins are effective.

The main side effects of these drugs are muscle pain and cramps. In some cases the muscle injury can be serious and indicate the cessation of treatment. Drug-induced hepatitis may also occur.

While statins act on triglycerides, fibrates are a class with stronger action for this purpose. Fibrates reduce triglycerides, but did not interfere in LDL.

Fibrates
Fibrates
 
Commonly used fibrates:
  • Fenofibrate
  • Bezafibrato
  • Gemfibrozil
  • Clofibrate
  • Ciprofibrate

The association between statins and fibrates should be done with caution, since there is an increased risk of muscle injury with concomitant use of these drugs.
Cholesterol drugs
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